• Around 537mn people worldwide have diabetes, while over 650mn are obese - and numbers are rising rapidly. With both conditions linked to a wide range of other serious medical issues, countering these two silent killers is one of the key healthcare and social challenges of the 21st century.
• Diabetes is not a new problem; however, the impact of modern lifestyles has resulted in a huge surge in cases of type-2 diabetes. Given the limited impact of public health campaigns, effective treatments are vital to reduce the social and economic cost.
• Being overweight is both a major cause of type-2 diabetes and a factor in numerous other diseases, including heart attacks, strokes, osteoarthritis and cancer. As obesity becomes recognised as a public health issue, the pathway to effective treatment is opening.

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